Tetrahydrofuran → 7-chloro-3-(4-dipropylaminomethyl-thiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one

HRID 287647Notes

Reaction equation

HRID 287647 reaction equation
[CH2:26]([CH2:27][CH3:28])[NH:29][CH2:30][CH2:31][CH3:32].[Cl:1][c:2]1[c:3]([F:25])[cH:4][cH:5][c:6]2[c:7]1[C:8](=[O:24])[N:9]([CH3:23])[CH2:10][c:11]1[n:12]-2[cH:13][n:14][c:15]1-[c:16]1[s:17][cH:18][c:19]([CH2:21][Cl:22])[n:20]1.[O:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1>>[Cl:1][c:2]1[c:3]([F:25])[cH:4][cH:5][c:6]2[c:7]1[C:8](=[O:24])[N:9]([CH3:23])[CH2:10][c:11]1[n:12]-2[cH:13][n:14][c:15]1-[c:16]1[s:17][cH:18][c:19]([CH2:21][N:29]([CH2:26][CH2:27][CH3:28])[CH2:30][CH2:31][CH3:32])[n:20]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 8902DipropylamineHCID 218422927-chloro-3-(4-chloromethyl-thiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one

Product 1

HCID 218422137-chloro-3-(4-dipropylaminomethyl-thiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one

Sources & evidence

ORD record
ord-20bb301f28ac4c13824253fa81f74bf4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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