N-benzyl-2-(1-hydroxycyclohexyl)-2-(2-naphthyl)acetamide → 1-[2-(benzylamino)-1-(2-naphthyl)ethyl]cyclohexanol Hydrochloride

HRID 28810Notes

Reaction equation

HRID 28810 reaction equation
[ClH:1].C(NC1CCCCC1(C(C1C=CC2C(=CC=CC=2)C=1)C)O)C1C=CC=CC=1.[CH2:29]([NH:36][C:37](=O)[CH:38]([C:49]1([OH:55])[CH2:54][CH2:53][CH2:52][CH2:51][CH2:50]1)[C:39]1[CH:48]=[CH:47][C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH:40]=1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[ClH:1].[CH2:29]([NH:36][CH2:37][CH:38]([C:49]1([OH:55])[CH2:50][CH2:51][CH2:52][CH2:53][CH2:54]1)[C:39]1[CH:48]=[CH:47][C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH:40]=1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

3

Reactant 2

HCID 68853191N-benzyl-2-(1-hydroxycyclohexyl)-2-(2-naphthyl)acetamideHCID 86600404HCID 86600404, compound

Product 1

HCID 115094641-[2-(benzylamino)-1-(2-naphthyl)ethyl]cyclohexanol Hydrochloride

Procedure

In an analogous manner to Example 1, step 2 1-[2-(benzylamino)[1-(2-naphthyl)ethyl]cyclohexanol hydrochloride was prepared from N-benzyl-2-(1-hydroxycyclohexyl)-2-(2-naphthyl)acetamide. HRMS: calcd for C25H29NO.HCl, 395.2016; found (ESI_FT), 360.23164.

Sources & evidence

ORD record
ord-1b1252f1fab34fc098416b51746d87ab
Source dataset
uspto-grants-2008_09
Patent number
US07419980B2

Reaction notes

Loading…