Hydrochloric Acid → HCID 68855539, compound

HRID 28811Notes

Reaction equation

HRID 28811 reaction equation
[ClH:1].Cl.[Br:3][C:4]1[CH:5]=[C:6]([CH:12]([C:21]([CH2:25][CH3:26])([OH:24])[CH2:22][CH3:23])[CH2:13][N:14]2[CH2:19][CH2:18][N:17](C)[CH2:16][CH2:15]2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11].BrC1C=C(C(C(CC)(O)CC)C(N2CCN(C(OC(C)(C)C)=O)CC2)=O)C=CC=1OC.Cl>>[ClH:1].[ClH:1].[Br:3][C:4]1[CH:5]=[C:6]([CH:12]([C:21]([CH2:22][CH3:23])([OH:24])[CH2:25][CH3:26])[CH2:13][N:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 68853420HCID 68853420, compoundHCID 68856152HCID 68856152, compound

Product 1

HCID 68855539HCID 68855539, compound

Procedure

In an analogous manner to Example 1, step 2 2-(3-bromo-4-methoxyphenyl)-3-ethyl-1-(4-methylpiperazin-1-yl)pentan-3-ol dihydrochloride was prepared from tert-butyl 4-[2-(3-bromo-4-methoxyphenyl)-3-ethyl-3-hydroxypentanoyl]piperazine-1-carboxylate. MS m/z 385/387 ([M+H]+); HRMS: calcd for C18H29BrN2O2.2.00 HCl, 456.0946; found (ESI), 385.1494.

Sources & evidence

ORD record
ord-170ff177481646b69abef8360d3073c2
Source dataset
uspto-grants-2008_09
Patent number
US07419980B2

Reaction notes

Loading…