Hydrochloric Acid → HCID 68853413, compound

HRID 28819Notes

Reaction equation

HRID 28819 reaction equation
Cl.Cl.NC1CCN(C2CCCCC2(CCC2C=C(C3C=CC([Cl:31])=C(Cl)C=3)C=CC=2)O)CC1.[Cl:33][C:34]1[CH:35]=[C:36]([C:41]2[CH:46]=[CH:45][CH:44]=[C:43]([CH:47]([C:63]3([OH:69])[CH2:68][CH2:67][CH2:66][CH2:65][CH2:64]3)[CH2:48][N:49]3[CH2:54][CH2:53][CH:52]([NH:55]C(=O)OC(C)(C)C)[CH2:51][CH2:50]3)[CH:42]=2)[CH:37]=[CH:38][C:39]=1[Cl:40].Cl>>[ClH:31].[ClH:33].[NH2:55][CH:52]1[CH2:53][CH2:54][N:49]([CH2:48][CH:47]([C:63]2([OH:69])[CH2:68][CH2:67][CH2:66][CH2:65][CH2:64]2)[C:43]2[CH:42]=[C:41]([C:36]3[CH:37]=[CH:38][C:39]([Cl:40])=[C:34]([Cl:33])[CH:35]=3)[CH:46]=[CH:45][CH:44]=2)[CH2:50][CH2:51]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 866004082-(4-Aminopiperidin-1-yl)-1-(3',4'-dichloro-1,1'-biphenyl-3-ylethyl]cyclohexanol dihydrochlorideHCID 86760725HCID 86760725, compound

Product 1

HCID 68853413HCID 68853413, compound

Procedure

In an analogous manner to Example 135, step 3 1-[2-(4-aminopiperidin-1-yl)-1-(3′,4′-dichloro-1,1′-biphenyl-3-ylethyl]cyclohexanol dihydrochloride was prepared from tert-butyl {1-[2-(3′,4′-dichloro-1,1′-biphenyl-3-yl)-2-(1-hydroxycyclohexyl)ethyl]piperidin-4-yl}carbamate. MS (ES) m/z 447.2 ([M+H]+); HRMS: calcd for C25H32Cl2N2O.2.00 HCl, 518.1425; found (ESI), 447.1962.

Sources & evidence

ORD record
ord-be5ecdc505f244f1bf7e85960f89423d
Source dataset
uspto-grants-2008_09
Patent number
US07419980B2

Reaction notes

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