1-{2-[(3S)-3-(methylamino)pyrrolidin-1-yl]-1-[3-(trifluoromethyl)phenyl]ethyl}cyclohexanol dihydrochloride → HCID 86599040, compound

HRID 28825Notes

Reaction equation

HRID 28825 reaction equation
[ClH:1].Cl.CN[C@H]1CCN([CH2:10][CH:11]([C:22]2([OH:28])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)C1.OC1(C(C2C=CC=C(C(F)(F)F)C=2)C([N:39]2[CH2:43][CH2:42][C@H:41]([NH:44][C:45](=O)OC(C)(C)C)[CH2:40]2)=O)CCCCC1>>[ClH:1].[ClH:1].[CH3:45][NH:44][C@H:41]1[CH2:42][CH2:43][N:39]([CH:27]2[CH2:26][CH2:25][CH2:24][CH2:23][C:22]2([CH:11]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:20])([F:21])[F:19])[CH:13]=2)[CH3:10])[OH:28])[CH2:40]1

Participants

3

Reactant 2

HCID 688656761-{2-[(3S)-3-(methylamino)pyrrolidin-1-yl]-1-[3-(trifluoromethyl)phenyl]ethyl}cyclohexanol dihydrochlorideHCID 86599042HCID 86599042, compound

Product 1

HCID 86599040HCID 86599040, compound

Procedure

In an analogous manner to Example 13, step 2, 1-{2-[(3S)-3-(methylamino)pyrrolidin-1-yl]-1-[3-(trifluoromethyl)phenyl]ethyl}cyclohexanol dihydrochloride was prepared from tert-butyl ((3S)-1-{(1-hydroxycyclohexyl)[3-(trifluoromethyl)phenyl]acetyl}pyrrolidin-3-yl)carbamate MS (ESI) m/z 371; HRMS: calcd for C20H29F3N2O+H, 371.23102; found (ESI, [M+H]+), 371.2293.

Sources & evidence

ORD record
ord-0757e3ac9c924a088b89e41a6d9ea277
Source dataset
uspto-grants-2008_09
Patent number
US07419980B2

Reaction notes

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