HRID28825

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN[C@H]1CCN(CC(c2cccc(C(F)(F)F)c2)C2(O)CCCCC2)C1.Cl.Cl

HCID68865676

未命名化合物

结构：CC(C)(C)OC(=O)N[C@H]1CCN(C(=O)C(c2cccc(C(F)(F)F)c2)C2(O)CCCCC2)C1

HCID86599042

未命名化合物

PRODUCTS

生成物

结构：CN[C@H]1CCN(C2CCCCC2(O)C(C)c2cccc(C(F)(F)F)c2)C1.Cl.Cl

HCID86599040

未命名化合物

PROCEDURE

实验过程

In an analogous manner to Example 13, step 2, 1-{2-[(3S)-3-(methylamino)pyrrolidin-1-yl]-1-[3-(trifluoromethyl)phenyl]ethyl}cyclohexanol dihydrochloride was prepared from tert-butyl ((3S)-1-{(1-hydroxycyclohexyl)[3-(trifluoromethyl)phenyl]acetyl}pyrrolidin-3-yl)carbamate MS (ESI) m/z 371; HRMS: calcd for C20H29F3N2O+H, 371.23102; found (ESI, [M+H]+), 371.2293.