Dichloromethane → Trifluoroacetic acid

HRID 288251Notes

Reaction equation

HRID 288251 reaction equation
[CH:1]([CH3:2])([CH3:3])[NH:4][C:5]([CH2:6][O:7][c:8]1[cH:9][c:10](-[c:14]2[n:15][c:16]3[cH:17][cH:18][cH:19][cH:20][c:21]3[c:22]([NH:24][c:25]3[cH:26][c:27]4[cH:28][n:29][n:30]([C:34]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:40])[c:31]4[cH:32][cH:33]3)[n:23]2)[cH:11][cH:12][cH:13]1)=[O:41].[Cl:49][CH2:50][Cl:51].[F:42][C:43]([C:44](=[O:45])[OH:46])([F:47])[F:48]>>[CH:1]([CH3:2])([CH3:3])[NH:4][C:5]([CH2:6][O:7][c:8]1[cH:9][c:10](-[c:14]2[n:15][c:16]3[cH:17][cH:18][cH:19][cH:20][c:21]3[c:22]([NH:24][c:25]3[cH:26][c:27]4[cH:28][n:29][nH:30][c:31]4[cH:32][cH:33]3)[n:23]2)[cH:11][cH:12][cH:13]1)=[O:41].[F:42][C:43]([C:44](=[O:45])[OH:46])([F:47])[F:48]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66826312tert-butyl 5-(2-(3-(2-(isopropylamino)-2-oxoethoxy)-phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 119501702-(3-(4-(1H-Indazol-5-ylamino)-2-quinazolinyl)phenoxy)-N-(1-methylethyl)acetamide

Sources & evidence

ORD record
ord-38512804e6214d34b1a751e53e4cbc47
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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