Dichloromethane → 5-Ethoxy-2-(3-(piperidin-4-ylidenemethyl)phenoxy)pyridine

HRID 288267Notes

Reaction equation

HRID 288267 reaction equation
[CH2:1]([CH3:2])[O:3][c:4]1[cH:5][cH:6][c:7]([O:10][c:11]2[cH:12][c:13]([CH:14]=[C:15]3[CH2:16][CH2:17][N:18]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:19][CH2:20]3)[cH:28][cH:29][cH:30]2)[n:8][cH:9]1.[Cl:38][CH2:39][Cl:40].[F:31][C:32]([F:33])([F:34])[C:35]([OH:36])=[O:37]>>[CH2:1]([CH3:2])[O:3][c:4]1[cH:5][cH:6][c:7]([O:10][c:11]2[cH:12][c:13]([CH:14]=[C:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[cH:28][cH:29][cH:30]2)[n:8][cH:9]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66876086tert-Butyl 4-(3-(5-ethoxypyridin-2-yloxy)benzylidene)piperidine-1-carboxylate

Product 1

HCID 668759965-Ethoxy-2-(3-(piperidin-4-ylidenemethyl)phenoxy)pyridine

Sources & evidence

ORD record
ord-dd142712a98748f1a1722eea7a8adc0f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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