Dimethyl Sulfoxide → tert-butyl 4-[6-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylate
Reaction equation
[CH3:53][CH2:54][O:55][C:56]([CH3:57])=[O:58].[CH3:59][S:60]([CH3:61])=[O:62].[Cl:15][c:16]1[n:17][c:18]([N:38]2[CH2:39][CH2:40][O:41][CH2:42][CH2:43]2)[c:19]2[c:20]([n:21]1)[n:22]([CH:25]1[CH2:26][CH2:27][N:28]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:29][CH2:30]1)[n:23][cH:24]2.[Cl:50][CH2:51][Cl:52].[F:1][CH:2]([c:3]1[n:4][c:5]2[c:6]([nH:7]1)[cH:8][cH:9][cH:10][c:11]2[O:12][CH3:13])[F:14].[K+:44].[K+:45].[O-:46][C:47]([O-:48])=[O:49].[OH2:63]>>[F:1][CH:2]([c:3]1[n:4][c:5]2[c:6]([n:7]1-[c:16]1[n:17][c:18]([N:38]3[CH2:39][CH2:40][O:41][CH2:42][CH2:43]3)[c:19]3[c:20]([n:21]1)[n:22]([CH:25]1[CH2:26][CH2:27][N:28]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:29][CH2:30]1)[n:23][cH:24]3)[cH:8][cH:9][cH:10][c:11]2[O:12][CH3:13])[F:14]Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-093bf12f51b44d3f88a811b6bc7d3060
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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