tert-butyl{(3R)-1-[(1-hydroxycyclohexyl)(2-naphthyl)acetyl]pyrrolidin-3-yl}carbamate → HCID 68854062, compound

HRID 28841Notes

Reaction equation

HRID 28841 reaction equation
[ClH:1].Cl.N[C@@H]1CCN(C2CCCCC2(C(C2C=CC3C(=CC=CC=3)C=2)C)O)C1.[OH:28][C:29]1([CH:35]([C:51]2[CH:60]=[CH:59][C:58]3[C:53](=[CH:54][CH:55]=[CH:56][CH:57]=3)[CH:52]=2)[C:36]([N:38]2[CH2:42][CH2:41][C@@H:40]([NH:43]C(=O)OC(C)(C)C)[CH2:39]2)=O)[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1>>[ClH:1].[ClH:1].[NH2:43][C@@H:40]1[CH2:41][CH2:42][N:38]([CH2:36][CH:35]([C:29]2([OH:28])[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[C:51]2[CH:60]=[CH:59][C:58]3[C:53](=[CH:54][CH:55]=[CH:56][CH:57]=3)[CH:52]=2)[CH2:39]1

Participants

3

Reactant 2

HCID 86599049tert-butyl{(3R)-1-[(1-hydroxycyclohexyl)(2-naphthyl)acetyl]pyrrolidin-3-yl}carbamateHCID 86600423HCID 86600423, compound

Product 1

HCID 68854062HCID 68854062, compound

Procedure

In an analogous manner to Example 1, step 2, 1-[2-[(3R)-3-aminopyrrolidin-1-yl]-1-(2-naphthyl)ethylcyclohexanol dihydrochloride was prepared from tert-butyl {(3R)-1-[(1-hydroxycyclohexyl)(2-naphthyl)acetyl]pyrrolidin-3-yl}carbamate. MS (ESI) m/z 339; HRMS: calcd for C22H30N2O+H+, 339.24309; found (ESI, [M+H]+), 339.243.

Sources & evidence

ORD record
ord-fdd39cd513c047619cf99a7e0873ef74
Source dataset
uspto-grants-2008_09
Patent number
US07419980B2

Reaction notes

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