反应详情

温度

-10 °C

In a 250-cm3 flask, 4 g of 2-(7-methoxy-1-naphthyl)ethanol are dissolved in 100 cm3 of dichloromethane, and 3.3 cm3 of triethylamine are added. The mixture is cooled in an ice bath at -10° C. and 2.75 g of mesyl chloride are then added dropwise and with stirring. The mixture is left stirring for 30 minutes. The aqueous phase is extracted with 3 times 50 cm3 of dichloromethane, and the organic phase is washed with 3 times 20 cm3 of 1N hydrochloric acid solution and then with water, dried over potassium carbonate and evaporated. The oily residue is recrystallized.

1. waitThe mixture is left
2. stirringstirring for 30 minutes
3. extractionThe aqueous phase is extracted with 3 times 50 cm3 of dichloromethane
4. washthe organic phase is washed with 3 times 20 cm3 of 1N hydrochloric acid solution
5. dry with materialwith water, dried over potassium carbonate
6. customevaporated
7. customThe oily residue is recrystallized