反应详情

A solution of {4-[1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}methylamine (0.16 mmol) in tetrahydrofuran (1 mL) was treated with triethylamine (0.17 mmol), and phenyl isocyanate (0.17 mmol). After stirring 18 h at room temperature the reaction was poured into water (1 mL), and extracted with (3×1 mL) ethyl acetate. The combined organic layers were washed with water (2×1 mL), brine (1×1 mL) dried over sodium sulfate and concentrated in vacuo. Purification of the residue by Gilson reverse phase HPLC provided the title product as a white powder (42%). ESMS [M+H]+: 437.2

1. extractionextracted with (3×1 mL) ethyl acetate
2. washThe combined organic layers were washed with water (2×1 mL), brine (1×1 mL)
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated in vacuo
5. customPurification of the residue by Gilson reverse phase HPLC