Dimethyl Sulfoxide → N-(5-chloro-2-pyridinyl)-2-[1-(5-fluoro-2-methylphenyl)pyrazolo[5,4-d]pyrimidin-4-yl]oxy-3-(2-hydroxyethoxy)propanamide

HRID 288574Notes

Reaction equation

HRID 288574 reaction equation
[C:19]([Si:20]([c:21]1[cH:22][cH:23][cH:58][cH:59][cH:60]1)([O:24][CH2:25][CH2:26][O:27][CH2:28][CH:29]([C:30](=[O:31])[NH:32][c:33]1[n:34][cH:35][c:36]([Cl:39])[cH:37][cH:38]1)[O:40][c:41]1[c:42]2[c:43]([n:44][cH:45][n:46]1)[n:47](-[c:50]1[c:51]([CH3:57])[cH:52][cH:53][c:54]([F:56])[cH:55]1)[n:48][cH:49]2)[c:61]1[cH:62][cH:63][cH:64][cH:65][cH:66]1)([CH3:67])([CH3:68])[CH3:69].[CH2:74]1[O:75][CH2:76][CH2:77][CH2:78]1.[CH3:2][CH2:3][CH2:4][CH2:5][N+:6]([CH2:7][CH2:8][CH2:9][CH3:10])([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:15][CH2:16][CH2:17][CH3:18].[CH3:70][S:71]([CH3:72])=[O:73].[F-:1]>>[OH:24][CH2:25][CH2:26][O:27][CH2:28][CH:29]([C:30](=[O:31])[NH:32][c:33]1[n:34][cH:35][c:36]([Cl:39])[cH:37][cH:38]1)[O:40][c:41]1[c:42]2[c:43]([n:44][cH:45][n:46]1)[n:47](-[c:50]1[c:51]([CH3:57])[cH:52][cH:53][c:54]([F:56])[cH:55]1)[n:48][cH:49]2

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 76550490HCID 76550490, compound

Product 1

HCID 76550405N-(5-chloro-2-pyridinyl)-2-[1-(5-fluoro-2-methylphenyl)pyrazolo[5,4-d]pyrimidin-4-yl]oxy-3-(2-hydroxyethoxy)propanamide

Sources & evidence

ORD record
ord-782731a230af450ca753d1eecdab6383
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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