N,N-Dimethylaniline → 4-(4-Chloro-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoic acid methylester

HRID 288578Notes

Reaction equation

HRID 288578 reaction equation
[CH3:27][N:28]([c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1)[CH3:35].[O:6]=[c:7]1[c:8]2[c:9]([n:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([C:17](=[O:18])[O:19][CH3:20])[cH:21][cH:22]3)[nH:12]1)[s:23][c:24]([CH3:26])[cH:25]2.[P:1]([Cl:2])([Cl:3])([Cl:4])=[O:5]>>[Cl:3][c:7]1[c:8]2[c:9]([n:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([C:17](=[O:18])[O:19][CH3:20])[cH:21][cH:22]3)[n:12]1)[s:23][c:24]([CH3:26])[cH:25]2

Participants

4

Reactant 3

HCID 949N,N-DimethylanilineHCID 24813Phosphorus oxychlorideHCID 23289523Methyl 4-(3,4-dihydro-4-oxo-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoate

Product 1

HCID 158405144-(4-Chloro-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoic acid methylester

Sources & evidence

ORD record
ord-4565a6adbfda47db9e747c2f3d03f013
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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