Dimethylformamide → 2-(2,4-Difluorophenylamino)-5-fluoro-6-methoxynicotinoyl chloride
Reaction equation
[CH2:37]([Cl:38])[Cl:39].[CH3:26][N:27]([CH3:28])[CH:29]=[O:30].[CH3:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36].[F:1][c:2]1[c:3]([NH:9][c:10]2[c:11]([C:12](=[O:13])[OH:14])[cH:15][c:16]([F:21])[c:17]([O:19][CH3:20])[n:18]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[S:22]([Cl:23])([Cl:24])=[O:25]>>[F:1][c:2]1[c:3]([NH:9][c:10]2[c:11]([C:12](=[O:13])[Cl:24])[cH:15][c:16]([F:21])[c:17]([O:19][CH3:20])[n:18]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1Participants
6
Sources & evidence
- ORD record
- ord-a7ecb1a5bf7347dda695d3de3cab1d5b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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