HRID28959

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCn1cc(-c2ccnc3c2cc(-c2ccc(NC(C)=O)cc2)n3S(=O)(=O)c2ccccc2)c(-c2ccc([N+](=O)[O-])cc2)n1

HCID69003853

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：CCn1cc(-c2ccnc3c2cc(-c2ccc(NC(C)=O)cc2)n3S(=O)(=O)c2ccccc2)c(-c2ccc(N)cc2)n1

HCID68997702

未命名化合物

收率 52%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID9942167

Palladium hydroxide

H2O2Pd

PROCEDURE

实验过程

A stirred solution of 4-[3-(4-nitrophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-(4-acetamidophenyl)-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine (0.8 mmol) and 20% palladium(II)hydroxide on carbon (0.1 g) was hydrogenated with a balloon of hydrogen for 3 days at room temperature. The reaction was filtered through a pad of Celite, rinsed with ethyl acetate and concentrated under vacuum to give the title product as an off-white solid (52%). ESMS [M+H]+: 577.4

WORKUP

后处理

filtrationThe reaction was filtered through a pad of Celite
washrinsed with ethyl acetate
concentrationconcentrated under vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-31d3b184ff6b4a739dbfbe615a81e87e
来源数据集: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07419988B2
来源说明: uspto-grants-2008_09

反应 SMILES

[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:14]([C:15]3[CH:20]=[CH:19][N:18]=[C:17]4[N:21]([S:34]([C:37]5[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=5)(=[O:36])=[O:35])[C:22]([C:24]5[CH:29]=[CH:28][C:27]([NH:30][C:31](=[O:33])[CH3:32])=[CH:26][CH:25]=5)=[CH:23][C:16]=34)=[CH:13][N:12]([CH2:43][CH3:44])[N:11]=2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>[OH-].[Pd+2].[OH-]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:14]([C:15]3[CH:20]=[CH:19][N:18]=[C:17]4[N:21]([S:34]([C:37]5[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=5)(=[O:35])=[O:36])[C:22]([C:24]5[CH:25]=[CH:26][C:27]([NH:30][C:31](=[O:33])[CH3:32])=[CH:28][CH:29]=5)=[CH:23][C:16]=34)=[CH:13][N:12]([CH2:43][CH3:44])[N:11]=2)=[CH:6][CH:5]=1