Sodium ion → 2-Fluoro-4-{8-[4-(1-methyl-piperidin-4-ylmethoxy)-phenylamino]-imidazo[1,2-a]pyrazin-5-yl}-benzamide
Reaction equation
[Br:1][c:2]1[cH:3][n:4][c:5]([NH:11][c:12]2[cH:13][cH:14][c:15]([O:18][CH2:19][CH:20]3[CH2:21][CH2:22][N:23]([CH3:26])[CH2:24][CH2:25]3)[cH:16][cH:17]2)[c:6]2[n:7]1[cH:8][cH:9][n:10]2.[C:46](=[O:47])([O-:48])[O-:49].[CH3:52][CH2:53][O:54][C:55](=[O:56])[CH3:57].[F:27][c:28]1[c:29]([C:30](=[O:31])[NH2:32])[cH:33][cH:34][c:35]([B:37]2[O:38][C:39]([CH3:40])([CH3:41])[C:42]([CH3:43])([CH3:44])[O:45]2)[cH:36]1.[Na+:50].[Na+:51].[O:58]1[CH2:59][CH2:60][O:61][CH2:62][CH2:63]1.[cH:64]1[cH:65][cH:66][c:67]([P:68]([Pd:69]([P:70]([c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)([c:77]2[cH:78][cH:79][cH:80][cH:81][cH:82]2)[c:83]2[cH:84][cH:85][cH:86][cH:87][cH:88]2)([P:89]([c:90]2[cH:91][cH:92][cH:93][cH:94][cH:95]2)([c:96]2[cH:97][cH:98][cH:99][cH:100][cH:101]2)[c:102]2[cH:103][cH:104][cH:105][cH:106][cH:107]2)[P:108]([c:109]2[cH:110][cH:111][cH:112][cH:113][cH:114]2)([c:115]2[cH:116][cH:117][cH:118][cH:119][cH:120]2)[c:121]2[cH:122][cH:123][cH:124][cH:125][cH:126]2)([c:127]2[cH:128][cH:129][cH:130][cH:131][cH:132]2)[c:133]2[cH:134][cH:135][cH:136][cH:137][cH:138]2)[cH:139][cH:140]1>>[c:2]1(-[c:35]2[cH:34][cH:33][c:29]([C:30](=[O:31])[NH2:32])[c:28]([F:27])[cH:36]2)[cH:3][n:4][c:5]([NH:11][c:12]2[cH:13][cH:14][c:15]([O:18][CH2:19][CH:20]3[CH2:21][CH2:22][N:23]([CH3:26])[CH2:24][CH2:25]3)[cH:16][cH:17]2)[c:6]2[n:7]1[cH:8][cH:9][n:10]2Participants
8
Reactant 7
HCID 923Sodium ion2×
HCID 8857Ethyl Acetate
HCID 19660Carbonate Ion
HCID 312751,4-Dioxane
HCID 590230642-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide
HCID 59023106(5-Bromo-imidazo[1,2-a]pyrazin-8-yl)-[4-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-amine
HCID 178420554HCID 178420554, compoundProduct 1
Sources & evidence
- ORD record
- ord-3526cee2685b46d7a052518e76d288ea
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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