Dimethylamine → N'-{4-[4-bromo-1-(1-methylethyl)-1H-pyrazol-3-yl]phenyl}-N,N-dimethylurea

HRID 28973Notes

Reaction equation

[Br:1][C:2]1[C:3]([C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)=[N:4][N:5]([CH:7]([CH3:9])[CH3:8])[CH:6]=1.[CH3:17][NH:18][CH3:19].[O:20]1[CH2:24]CCC1>>[Br:1][C:2]1[C:3]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:24](=[O:20])[N:18]([CH3:19])[CH3:17])=[CH:12][CH:11]=2)=[N:4][N:5]([CH:7]([CH3:9])[CH3:8])[CH:6]=1

Participants

Reactant 3

HCID 674Dimethylamine

HCID 8028Tetrahydrofuran

HCID 69001927HCID 69001927, compound

Product 1

HCID 68997969N'-{4-[4-bromo-1-(1-methylethyl)-1H-pyrazol-3-yl]phenyl}-N,N-dimethylurea

Procedure

Following the procedure described in Example 5a using {4-[4-bromo-1-(1-methylethyl)-1H-pyrazol-3-yl]phenyl}amine and 2M dimethylamine in tetrahydrofuran provided the title compound. ESMS [M+H]+: 351.2

Sources & evidence

ORD record: ord-e666336a1da64e2b9406f03ed9e539ad
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07419988B2

Reaction notes

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