Pyrrolidine → HCID 68998916, compound

HRID 28985Notes

Reaction equation

[CH2:1]([N:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]3[N:14]([S:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)(=[O:28])=[O:27])[C:15]([C:17]4[CH:24]=[CH:23][C:20]([CH:21]=O)=[C:19]([F:25])[CH:18]=4)=[CH:16][C:9]=23)[C:5]([C:35]2[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][CH:36]=2)=[N:4]1)[CH3:2].[NH:44]1[CH2:48][CH2:47][CH2:46][CH2:45]1>>[CH2:1]([N:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]3[N:14]([S:26]([C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=4)(=[O:27])=[O:28])[C:15]([C:17]4[CH:24]=[CH:23][C:20]([CH2:21][N:44]5[CH2:48][CH2:47][CH2:46][CH2:45]5)=[C:19]([F:25])[CH:18]=4)=[CH:16][C:9]=23)[C:5]([C:35]2[CH:36]=[CH:37][C:38]([N+:41]([O-:43])=[O:42])=[CH:39][CH:40]=2)=[N:4]1)[CH3:2]

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 86613329HCID 86613329, compound

Product 1

HCID 68998916HCID 68998916, compound

Procedure

Following the procedure described for Intermediate 101 using 4-[4-[1-ethyl-3-(4-nitrophenyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-fluorobenzaldehyde and pyrrolidine provided the title compound. ESMS[M+H]+: 651.4.

Sources & evidence

ORD record: ord-434d3c1c5fb448bca2db2f43899ff8c5
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07419988B2

Reaction notes

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