Dichloromethane → tert-Butyl 3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzylcarbamate

HRID 290274Notes

Reaction equation

HRID 290274 reaction equation
[CH3:32][CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38].[Cl:39][c:40]1[c:41]([OH:51])[c:42]([S:47](=[O:48])(=[O:49])[Cl:50])[cH:43][c:44]([Cl:46])[cH:45]1.[Cl:52][CH2:53][Cl:54].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][cH:10][c:11]([CH2:14][NH:15][CH2:16][c:17]3[cH:18][c:19]([CH2:20][NH:21][C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[cH:29][cH:30][cH:31]3)[cH:12][cH:13]2)[cH:6][cH:7]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][cH:10][c:11]([CH2:14][N:15]([CH2:16][c:17]3[cH:18][c:19]([CH2:20][NH:21][C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[cH:29][cH:30][cH:31]3)[S:47]([c:42]3[c:41]([OH:51])[c:40]([Cl:39])[cH:45][c:44]([Cl:46])[cH:43]3)(=[O:48])=[O:49])[cH:12][cH:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 900783,5-Dichloro-2-hydroxybenzenesulphonyl chlorideHCID 58531402tert-Butyl 3-(((4'-fluorobiphenyl-4-yl)methylamino)methyl)benzylcarbamate

Product 1

HCID 58531334tert-Butyl 3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzylcarbamate

Sources & evidence

ORD record
ord-6d1318551bbf446c872d6fb957700249
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…