Dichloromethane → 2-[4-[4-[[2-Phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]phenyl]benzoyl]cyclopentane-1-carboxylic acid

HRID 290594Notes

Reaction equation

HRID 290594 reaction equation
[Br:26][P+:27]([N:28]1[CH2:29][CH2:30][CH2:31][CH2:32]1)([N:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1)[N:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1.[CH2:75]([Cl:76])[Cl:77].[CH:66]([N:67]([CH:68]([CH3:69])[CH3:70])[CH2:71][CH3:72])([CH3:73])[CH3:74].[NH2:43][c:44]1[cH:45][cH:46][c:47](-[c:50]2[cH:51][cH:52][c:53]([C:56](=[O:57])[CH:58]3[CH:59]([C:63](=[O:64])[OH:65])[CH2:60][CH2:61][CH2:62]3)[cH:54][cH:55]2)[cH:48][cH:49]1.[P-:19]([F:20])([F:21])([F:22])([F:23])([F:24])[F:25].[c:1]1(-[c:7]2[o:8][c:9]([C:15]([F:16])([F:17])[F:18])[c:10]([C:12](=[O:13])[OH:14])[n:11]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1(-[c:7]2[o:8][c:9]([C:15]([F:16])([F:17])[F:18])[c:10]([C:12](=[O:14])[NH:43][c:44]3[cH:45][cH:46][c:47](-[c:50]4[cH:51][cH:52][c:53]([C:56](=[O:57])[CH:58]5[CH:59]([C:63](=[O:64])[OH:65])[CH2:60][CH2:61][CH2:62]5)[cH:54][cH:55]4)[cH:48][cH:49]3)[n:11]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 2733180Bromotripyrrolidin-1-ylphosphoniumHCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 219856862-[4-(4-Aminophenyl)benzoyl]cyclopentane-1-carboxylic acid

Product 1

HCID 667382262-[4-[4-[[2-Phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]phenyl]benzoyl]cyclopentane-1-carboxylic acid

Sources & evidence

ORD record
ord-e909e75f791f44a3bc5aa01910ad0ed7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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