Trifluoroacetic acid → 2-amino-1-[(2S)-2-(2-benzyltetrazol-5-yl)pyrrolidin-1-yl]-2-cyclohexylethanone;2,2,2-trifluoroacetic acid

HRID 29076Notes

Reaction equation

HRID 29076 reaction equation
C(OC(=O)[NH:7][CH:8]([CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1)[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[C:16]1[N:17]=[N:18][N:19]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:20]=1)=[O:10])(C)(C)C.[C:35]([OH:41])([C:37]([F:40])([F:39])[F:38])=[O:36]>C(Cl)Cl>[F:38][C:37]([F:40])([F:39])[C:35]([OH:41])=[O:36].[NH2:7][CH:8]([CH:28]1[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]1)[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[C:16]1[N:17]=[N:18][N:19]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:20]=1)=[O:10]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59787961{2-[(S)-2-(2-Benzyl-2H-tetrazol-5-yl)-pyrrolidin-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester

Product 1

HCID 866010842-amino-1-[(2S)-2-(2-benzyltetrazol-5-yl)pyrrolidin-1-yl]-2-cyclohexylethanone;2,2,2-trifluoroacetic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound E in DCM (4 mL) is added TFA (4 mL) at 0° C. The solution is stirred at room temperature for 1 hr and dried under vacuum. The crude oil is used directly in the next step without further purification. M+H+=369.

Workup

  1. customdried under vacuum
  2. customThe crude oil is used directly in the next step without further purification

Sources & evidence

ORD record
ord-cd8c9dad05254e29938d6e731d6f2b60
Source dataset
uspto-grants-2008_09
Patent number
US07419975B2

Reaction notes

Loading…