Trifluoroacetic acid → Pyrrolidine-2-carbaldehyde-O-benzyl-oxime

HRID 29079Notes

Reaction equation

HRID 29079 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH:13]=[N:14][O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:16]([O:15][N:14]=[CH:13][CH:9]1[CH2:10][CH2:11][CH2:12][NH:8]1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 866010862-(Benzyloxyimino-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 72562396Pyrrolidine-2-carbaldehyde-O-benzyl-oxime

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The solution of 2-(benzyloxyimino-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (1.50 g, 4.92 mmole) and TFA (10 ml) in dichloromethane (10 ml) is stirred for 2 hours at room temperature. Solvent is removed. The crude product is carried to next step without further purification. M+H+=205.1

Workup

  1. customSolvent is removed
  2. customThe crude product is carried to next step without further purification

Sources & evidence

ORD record
ord-73f80f4d06b44e239e40ae1da98f6e6c
Source dataset
uspto-grants-2008_09
Patent number
US07419975B2

Reaction notes

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