Dichloromethane → (3-Hydroxy-3-methyl-pyrrolidin-1-yl)-[2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl]-methanone

HRID 290836Notes

Reaction equation

HRID 290836 reaction equation
[CH2:57]([N:58]([CH2:59][CH3:60])[CH2:61][CH3:62])[CH3:63].[CH3:1][O:2][c:3]1[cH:4][c:5]([CH:9]2[NH:10][c:11]3[cH:12][cH:13][c:14]([C:21](=[O:22])[OH:23])[cH:15][c:16]3[CH2:17][C:18]2([CH3:19])[CH3:20])[cH:6][cH:7][cH:8]1.[CH3:24][NH3+:25].[CH3:64][C:65]1([OH:70])[CH2:66][NH:67][CH2:68][CH2:69]1.[Cl:71][CH2:72][Cl:73].[F:26][P-:27]([F:28])([F:29])([F:30])([F:31])[F:32].[F:50][P-:51]([F:52])([F:53])([F:54])([F:55])[F:56].[n:33]1([O:34][C:35]([N:36]([CH3:37])[CH3:38])=[N+:39]([CH3:40])[CH3:41])[c:42]2[n:43][cH:44][cH:45][cH:46][c:47]2[n:48][n:49]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]([CH:9]2[NH:10][c:11]3[cH:12][cH:13][c:14]([C:21](=[O:22])[N:67]4[CH2:66][C:65]([CH3:64])([OH:70])[CH2:69][CH2:68]4)[cH:15][c:16]3[CH2:17][C:18]2([CH3:19])[CH3:20])[cH:6][cH:7][cH:8]1

Participants

8

Reactant 7

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 9886Hexafluorophosphate2×HCID 644041MethylammoniumHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 145784583-Methylpyrrolidin-3-olHCID 674412162-(3-Methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid

Product 1

HCID 58476155(3-Hydroxy-3-methyl-pyrrolidin-1-yl)-[2-(3-methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl]-methanone

Sources & evidence

ORD record
ord-e95f47710b8b4a56926a633f58c9de77
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…