Acetic Acid → HCID 69314293, compound

Temperature

-78 °C

A NaHMDS solution in THF (112 mL, 1.0 M) was diluted with 50 mL of dry THF and cooled to −78° C. A solution of cyclohexanone (10.6 mL, 102 mmol) in 50 mL of dry THF was added dropwise over 10 min. After the addition, the mixture was allowed to warm to room temperature and stirred at 0° C. for 15 min before it was cooled to −78° C. again. A pre-cooled solution of methyl 2-[(4-fluorophenyl)methylene]-4-methyl-3-oxo-pentanoic acid (30.7 g, 123 mmol) in 30 mL of dry THF at −78° C. was added quickly via a cannula. The reaction mixture was stirred at −78° C. for 3 h and quenched with acetic acid (30 mL, 524 mmol) in 30 mL of THF. After warming to room temperature the reaction was diluted with 50 mL of water and extracted with ethyl acetate (3×100 mL). The organic fractions were combined, washed with saturated aqueous sodium chloride solution (100 mL), dried over magnesium sulfate, filtered and concentrated in vacuum to provide methyl 4-fluoro-α-(1-oxo-2-methylpropyl)-β-(2-oxocyclohexyl)benzenepropanoate a pale yellow oil: LCMS (method 5) tR=2.1 min; (ESI, pos. ion spectrum) m/z 349 (M+H).

1. additionAfter the addition
2. temperatureto warm to room temperature
3. temperaturewas cooled to −78° C. again
4. stirringThe reaction mixture was stirred at −78° C. for 3 h
5. temperatureAfter warming to room temperature the reaction
6. extractionextracted with ethyl acetate (3×100 mL)
7. washwashed with saturated aqueous sodium chloride solution (100 mL)
8. dry with materialdried over magnesium sulfate
9. filtrationfiltered
10. concentrationconcentrated in vacuum

ORD record

ord-ad3c9718191e46fb9a2b43ed116b7a90

Source dataset

uspto-grants-2008_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07420059B2