Water → (+/-)-alpha-(1-butyl-1H-imidazol-5-yl)-4-(3-chlorophenyl)-alpha-(4-chlorophenyl)-2-methoxy-6-quinolinemethanol

HRID 291076Notes

Reaction equation

HRID 291076 reaction equation
[Br:6][c:7]1[cH:8][c:9]2[c:10](-[c:19]3[cH:20][c:21]([Cl:25])[cH:22][cH:23][cH:24]3)[cH:11][c:12]([O:17][CH3:18])[n:13][c:14]2[cH:15][cH:16]1.[CH2:26]([CH2:27][CH2:28][CH3:29])[n:30]1[cH:31][n:32][cH:33][c:34]1[C:35](=[O:36])[c:37]1[cH:38][cH:39][c:40]([Cl:43])[cH:41][cH:42]1.[CH2:51]1[O:52][CH2:53][CH2:54][CH2:55]1.[CH3:45][CH2:46][CH2:47][CH2:48][CH2:49][CH3:50].[Li:1][CH2:2][CH2:3][CH2:4][CH3:5].[OH2:44]>>[c:7]1([C:35]([c:34]2[n:30]([CH2:26][CH2:27][CH2:28][CH3:29])[cH:31][n:32][cH:33]2)([OH:36])[c:37]2[cH:38][cH:39][c:40]([Cl:43])[cH:41][cH:42]2)[cH:8][c:9]2[c:10](-[c:19]3[cH:20][c:21]([Cl:25])[cH:22][cH:23][cH:24]3)[cH:11][c:12]([O:17][CH3:18])[n:13][c:14]2[cH:15][cH:16]1

Participants

7

Reactant 6

HCID 962WaterHCID 8028TetrahydrofuranHCID 8058HexaneHCID 120166726-Bromo-4-(3-chlorophenyl)-2-methoxyquinolineHCID 22714358(1-butyl-1H-imidazol-5-yl)(4-chlorophenyl)methanoneHCID 178418339Butyllithium

Product 1

HCID 22714345(+/-)-alpha-(1-butyl-1H-imidazol-5-yl)-4-(3-chlorophenyl)-alpha-(4-chlorophenyl)-2-methoxy-6-quinolinemethanol

Sources & evidence

ORD record
ord-b07d2af963ca4ed8a4a5fccaef626576
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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