Dichloromethane → 3-(Trifluoromethyl)-5,6-dihydro-1,6-naphthyridin-7(8H)-one

HRID 291814Notes

Reaction equation

HRID 291814 reaction equation
[CH2:30]([Cl:31])[Cl:32].[O:1]=[C:2]1[NH:3][CH2:4][c:5]2[cH:6][c:7]([C:19]([F:20])([F:21])[F:22])[cH:8][n:9][c:10]2[CH:11]1[C:12]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:18].[OH:23][C:24]([C:25]([F:26])([F:27])[F:28])=[O:29]>>[O:1]=[C:2]1[NH:3][CH2:4][c:5]2[cH:6][c:7]([C:19]([F:20])([F:21])[F:22])[cH:8][n:9][c:10]2[CH2:11]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59017436Tert-butyl 7-oxo-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-8-carboxylate

Product 1

HCID 235336283-(Trifluoromethyl)-5,6-dihydro-1,6-naphthyridin-7(8H)-one

Sources & evidence

ORD record
ord-f01101809e354f2e9d56015e8fd85b51
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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