Methanesulfonic Acid → N-(cyanomethyl)-1-[4'-(1-piperazinyl)[1,1'-biphenyl]-3-yl]-2-piperidinecarboxamide

HRID 292309Notes

Reaction equation

HRID 292309 reaction equation
[C:1](#[N:2])[CH2:3][NH:4][C:5](=[O:6])[CH:7]1[N:8]([c:13]2[cH:14][c:15](-[c:19]3[cH:20][cH:21][c:22]([N:25]4[CH2:26][CH2:27][N:28]([C:31]([O:32][C:33]([CH3:34])([CH3:35])[CH3:36])=[O:37])[CH2:29][CH2:30]4)[cH:23][cH:24]3)[cH:16][cH:17][cH:18]2)[CH2:9][CH2:10][CH2:11][CH2:12]1.[CH3:38][S:39](=[O:40])(=[O:41])[OH:42].[O:43]1[CH2:44][CH2:45][O:46][CH2:47][CH2:48]1>>[C:1](#[N:2])[CH2:3][NH:4][C:5](=[O:6])[CH:7]1[N:8]([c:13]2[cH:14][c:15](-[c:19]3[cH:20][cH:21][c:22]([N:25]4[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]4)[cH:23][cH:24]3)[cH:16][cH:17][cH:18]2)[CH2:9][CH2:10][CH2:11][CH2:12]1

Participants

4

Reactant 3

HCID 6395Methanesulfonic AcidHCID 312751,4-DioxaneHCID 22236171Tert-butyl 4-[3'-(2-{[(cyanomethyl)amino]carbonyl}-1-piperidinyl)[1,1'-biphenyl]-4-yl]-1-piperazinecarboxylate

Product 1

HCID 22235838N-(cyanomethyl)-1-[4'-(1-piperazinyl)[1,1'-biphenyl]-3-yl]-2-piperidinecarboxamide

Sources & evidence

ORD record
ord-08f07ae6f34843f493209189744e8962
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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