p-Toluenesulfonic acid → HCID 68716235, compound

Participants

Reaction Steps

To a solution of 0.150 g (0.568 mmol) of 4-(1,2-dihydroxyethyl)-3-methylbenzofuran-2-carboxylic acid ethyl ester dissolved in 5 mL of acetone was added 0.010 g of p-toluenesulfonic acid and the reaction was stirred at room temperature overnight. Saturated sodium bicarbonate was added and the acetone was removed in vacuo. The residue was extracted with ether, the organics were dried over sodium sulfate, filtered and concentrated in vacuo. The residue was chromatographed on silica gel eluting with ethyl acetate/hexanes (1:5) to provide 0.172 g of 4-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-methylbenzofuran-2-carboxylic acid ethyl ester.

Provenance & Evidence