反应详情

To a solution of 0.150 g (0.568 mmol) of 4-(1,2-dihydroxyethyl)-3-methylbenzofuran-2-carboxylic acid ethyl ester dissolved in 5 mL of acetone was added 0.010 g of p-toluenesulfonic acid and the reaction was stirred at room temperature overnight. Saturated sodium bicarbonate was added and the acetone was removed in vacuo. The residue was extracted with ether, the organics were dried over sodium sulfate, filtered and concentrated in vacuo. The residue was chromatographed on silica gel eluting with ethyl acetate/hexanes (1:5) to provide 0.172 g of 4-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-methylbenzofuran-2-carboxylic acid ethyl ester.

1. customthe acetone was removed in vacuo
2. extractionThe residue was extracted with ether
3. dry with materialthe organics were dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customThe residue was chromatographed on silica gel eluting with ethyl acetate/hexanes (1:5)