Dichloromethane → N-[3-(3-{2-[(3-{[2-(dimethylamino)ethyl]oxy}phenyl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]-2-(3-thienyl)acetamide

HRID 293505Notes

Reaction equation

HRID 293505 reaction equation
[CH2:69]1[O:70][CH2:71][CH2:72][CH2:73]1.[Cl:74][CH2:75][Cl:76].[NH2:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][n:10]3[c:11]([cH:12][cH:13][cH:14][cH:15]3)[c:16]2-[c:17]2[n:18][c:19]([NH:23][c:24]3[cH:25][c:26]([O:30][CH2:31][CH2:32][N:33]([CH3:34])[CH3:35])[cH:27][cH:28][cH:29]3)[n:20][cH:21][cH:22]2)[cH:5][cH:6][cH:7]1.[P-:45]([F:46])([F:47])([F:48])([F:49])([F:50])[F:51].[n:52]1([O:53][C:54]([N:55]([CH3:56])[CH3:57])=[N+:58]([CH3:59])[CH3:60])[c:61]2[n:62][cH:63][cH:64][cH:65][c:66]2[n:67][n:68]1.[s:36]1[cH:37][c:38]([CH2:41][C:42](=[O:43])[OH:44])[cH:39][cH:40]1>>[NH:1]([c:2]1[cH:3][c:4](-[c:8]2[n:9][n:10]3[c:11]([cH:12][cH:13][cH:14][cH:15]3)[c:16]2-[c:17]2[n:18][c:19]([NH:23][c:24]3[cH:25][c:26]([O:30][CH2:31][CH2:32][N:33]([CH3:34])[CH3:35])[cH:27][cH:28][cH:29]3)[n:20][cH:21][cH:22]2)[cH:5][cH:6][cH:7]1)[C:42]([CH2:41][c:38]1[cH:37][s:36][cH:40][cH:39]1)=[O:43]

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 9886HexafluorophosphateHCID 234043-Thiophenacetic acidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 577371664-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(3-{[2-(dimethylamino)ethyl]oxy}phenyl)-2-pyrimidinamine

Product 1

HCID 57737236N-[3-(3-{2-[(3-{[2-(dimethylamino)ethyl]oxy}phenyl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]-2-(3-thienyl)acetamide

Sources & evidence

ORD record
ord-15306045a6df483c9ef01f273fd6bb28
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…