Imidazole → 3-[5-(tert-Butyldimethylsilanyloxy)-5-(4-fluorophenyl)pentanoyl]4-phenyloxazolidin-2-one

HRID 293512Notes

Reaction equation

HRID 293512 reaction equation
[C:32]([CH3:33])([CH3:34])([CH3:35])[Si:36]([CH3:37])([CH3:38])[Cl:39].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH2:9][CH2:10][CH2:11][C:12](=[O:13])[N:14]2[C:15](=[O:25])[O:16][CH2:17][CH:18]2[c:19]2[cH:20][cH:21][cH:22][cH:23][cH:24]2)[OH:26])[cH:6][cH:7]1.[O:40]=[CH:41][N:42]([CH3:43])[CH3:44].[nH:27]1[cH:28][cH:29][n:30][cH:31]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH2:9][CH2:10][CH2:11][C:12](=[O:13])[N:14]2[C:15](=[O:25])[O:16][CH2:17][CH:18]2[c:19]2[cH:20][cH:21][cH:22][cH:23][cH:24]2)[O:26][Si:36]([C:32]([CH3:33])([CH3:34])[CH3:35])([CH3:37])[CH3:38])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 28928tert-Butyldimethylsilyl chlorideHCID 121116173-[5-(4-Fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-2-oxazolidinone

Product 1

HCID 121116183-[5-(tert-Butyldimethylsilanyloxy)-5-(4-fluorophenyl)pentanoyl]4-phenyloxazolidin-2-one

Sources & evidence

ORD record
ord-0571b7b2ecea43adae88e4268127d3be
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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