Sodium ion → 1-[4-[4-Chloro-2-(hydroxymethyl)-5-methoxyphenyl]piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone

HRID 293608Notes

Reaction equation

HRID 293608 reaction equation
[BH4-:32].[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[Cl:1][c:2]1[c:3]([O:30][CH3:31])[cH:4][c:5]([N:10]2[CH2:11][CH2:12][N:13]([C:16]([CH2:17][n:18]3[n:19][c:20]([C:25]([F:26])([F:27])[F:28])[c:21]([Cl:24])[c:22]3[CH3:23])=[O:29])[CH2:14][CH2:15]2)[c:6]([CH:7]=[O:8])[cH:9]1.[Na+:33]>>[Cl:1][c:2]1[c:3]([O:30][CH3:31])[cH:4][c:5]([N:10]2[CH2:11][CH2:12][N:13]([C:16]([CH2:17][n:18]3[n:19][c:20]([C:25]([F:26])([F:27])[F:28])[c:21]([Cl:24])[c:22]3[CH3:23])=[O:29])[CH2:14][CH2:15]2)[c:6]([CH2:7][OH:8])[cH:9]1

Participants

5

Reactant 4

HCID 923Sodium ionHCID 8028TetrahydrofuranHCID 28123BorohydrideHCID 578401785-Chloro-2-[4-[2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]piperazin-1-yl]-4-methoxybenzaldehyde

Product 1

HCID 578403001-[4-[4-Chloro-2-(hydroxymethyl)-5-methoxyphenyl]piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone

Sources & evidence

ORD record
ord-af225af8c68949fc8fc1de3e2c7c74ae
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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