Toluene → (2-Isopropylthiazol-5-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone

HRID 294055Notes

Reaction equation

HRID 294055 reaction equation
[CH3:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1.[CH:8]([CH3:9])([CH3:10])[c:11]1[s:12][c:13]([C:16](=[O:17])[N:18]2[CH2:19][CH2:20][O:21][C:22]3([CH2:23]2)[CH2:24][CH2:25][N:26]([C:29]([O:30][C:31]([CH3:32])([CH3:33])[CH3:34])=[O:35])[CH2:27][CH2:28]3)[cH:14][n:15]1.[Cl:43][CH2:44][Cl:45].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[CH:8]([CH3:9])([CH3:10])[c:11]1[s:12][c:13]([C:16](=[O:17])[N:18]2[CH2:19][CH2:20][O:21][C:22]3([CH2:23]2)[CH2:24][CH2:25][NH:26][CH2:27][CH2:28]3)[cH:14][n:15]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57989386tert-Butyl 4-(2-isopropylthiazole-5-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Product 1

HCID 57989156(2-Isopropylthiazol-5-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone

Sources & evidence

ORD record
ord-814f13fa7cff4855a3d277a93eea6eaf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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