Bromide ion → (+/-)(3,5-Difluorophenyl)(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanol

HRID 294282Notes

Reaction equation

HRID 294282 reaction equation
[Br-:1].[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[F:16][c:17]1[cH:18][c:19]([CH:20]=[O:21])[cH:22][c:23]([F:25])[cH:24]1.[O:2]1[CH:3]([O:8][c:9]2[cH:10][cH:11][c:12]([Mg+:15])[cH:13][cH:14]2)[CH2:4][CH2:5][CH2:6][CH2:7]1>>[O:2]1[CH:3]([O:8][c:9]2[cH:10][cH:11][c:12]([CH:20]([c:19]3[cH:18][c:17]([F:16])[cH:24][c:23]([F:25])[cH:22]3)[OH:21])[cH:13][cH:14]2)[CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

5

Reactant 4

HCID 259Bromide ionHCID 8028TetrahydrofuranHCID 5881603,5-DifluorobenzaldehydeHCID 178507021HCID 178507021, compound

Product 1

HCID 57835854(+/-)(3,5-Difluorophenyl)(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanol

Sources & evidence

ORD record
ord-0ed8be1dc7e64c82ad33154fd6987179
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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