反应详情

温度

110 °C

To 2-aminophenol (437 mg, 4 mmol) was added ethyl triethoxyacetate (3.5 g, 4 eq). The mixture was stirred at 110° C. overnight. The reaction mixture was cooled and triturated with hexane. Filtration gave 516 mg of benzoxazole-2-carboxylic acid ethyl ester as a white solid.

1. temperatureThe reaction mixture was cooled
2. customtriturated with hexane
3. filtrationFiltration