HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29432Generated: October 29, 2026
2-Aminophenol → Ethyl 1,3-benzoxazole-2-carboxylate
https://huagongshe.com/reaction/29432
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Aminophenol | HCID 5801 | — |
| Reactant | Ethyl 2,2,2-triethoxyacetate | HCID 5090273 | — |
| Product | Ethyl 1,3-benzoxazole-2-carboxylate | HCID 14220914 | 67.5% |
Reaction Steps
To 2-aminophenol (437 mg, 4 mmol) was added ethyl triethoxyacetate (3.5 g, 4 eq). The mixture was stirred at 110° C. overnight. The reaction mixture was cooled and triturated with hexane. Filtration gave 516 mg of benzoxazole-2-carboxylic acid ethyl ester as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07420001B2 |
|---|
| Source dataset | uspto-grants-2008_09 |
|---|
| ORD ID | ord-65ea146735684dce99300d1e899b6c38 |
|---|
| Source note | uspto-grants-2008_09 |
|---|
