Sodium Hydroxide → HCID 68714301, compound

HRID 29437Notes

Reaction equation

HRID 29437 reaction equation
C([O:3][C:4]([C:6]1[O:7][C:8]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[C:9]=2[N:10]=1)=[O:5])C.[OH-].[Na+:17]>C1COCC1>[Na+:17].[CH3:15][C:11]1[C:9]2[N:10]=[C:6]([C:4]([O-:5])=[O:3])[O:7][C:8]=2[CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 687152764-Methyl-benzooxazole-2-carboxylic acid ethyl ester

Product 1

HCID 68714301HCID 68714301, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 4-methyl-benzooxazole-2-carboxylic acid ethyl ester (140 mg) was added 2 mL of THF, and 0.93 mL (2 eq) of NaOH solution (2N in MeOH). The reaction mixture was stirred at room temperature overnight. The suspension was filtered and the solid was dried under vacuum to give 200 mg (100%) of 4-methyl-benzooxazole-2-carboxylic acid sodium salt as an off-white solid.

Workup

  1. filtrationThe suspension was filtered
  2. customthe solid was dried under vacuum

Sources & evidence

ORD record
ord-c031bac3eb294a1eb6cabf9b0167d3e4
Source dataset
uspto-grants-2008_09
Patent number
US07420001B2

Reaction notes

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