Sodium Hydroxide → 5-Trifluoromethyl-benzothiazole-2-carboxylic acid sodium salt

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Reaction Steps

To 5-trifluoromethyl-benzothiazole-2-carboxylic acid ethyl ester (200 mg, 0.73 mmol) was added 3 mL of THF, and 0.73 mL (2 eq) of NaOH solution (2N in MeOH). The reaction mixture was stirred at room temperature overnight. The suspension was filtered and the solid was dried under vacuum to give 270 mg of 5-trifluoromethyl-benzothiazole-2-carboxylic acid sodium salt as an off-white solid.

Provenance & Evidence