Sodium Hydroxide → 5-Trifluoromethyl-benzothiazole-2-carboxylic acid sodium salt

HRID 29449Notes

Reaction equation

HRID 29449 reaction equation
C([O:3][C:4]([C:6]1[S:7][C:8]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:9]=2[N:10]=1)=[O:5])C.[OH-].[Na+:20]>C1COCC1>[Na+:20].[F:18][C:15]([F:16])([F:17])[C:12]1[CH:13]=[CH:14][C:8]2[S:7][C:6]([C:4]([O-:5])=[O:3])=[N:10][C:9]=2[CH:11]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 551898085-Trifluoromethyl-benzothiazole-2-carboxylic acid ethyl ester

Product 1

HCID 687139225-Trifluoromethyl-benzothiazole-2-carboxylic acid sodium salt

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 5-trifluoromethyl-benzothiazole-2-carboxylic acid ethyl ester (200 mg, 0.73 mmol) was added 3 mL of THF, and 0.73 mL (2 eq) of NaOH solution (2N in MeOH). The reaction mixture was stirred at room temperature overnight. The suspension was filtered and the solid was dried under vacuum to give 270 mg of 5-trifluoromethyl-benzothiazole-2-carboxylic acid sodium salt as an off-white solid.

Workup

  1. filtrationThe suspension was filtered
  2. customthe solid was dried under vacuum

Sources & evidence

ORD record
ord-0b2521f6bded4aad9c968d497fe761a9
Source dataset
uspto-grants-2008_09
Patent number
US07420001B2

Reaction notes

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