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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 294748Generated: October 26, 2026

Methanol → 8-Chloro-3-(difluoromethoxy)-1,5-naphthyridine

https://huagongshe.com/reaction/294748

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantSodium ionHCID 923—
ReactantDimethylformamideHCID 6228—
ReactantDichloromethaneHCID 6344—
ReactantCarbonate IonHCID 19660—
ReactantCesium cationHCID 104967—
Reactant2-Chloro-2,2-difluoroacetateHCID 3763046—
Reactant8-Chloro-1,5-naphthyridin-3-olHCID 135743576—
Product8-Chloro-3-(difluoromethoxy)-1,5-naphthyridineHCID 57691291—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (8/10)
ORD IDord-6644e33555f940df924ff33b6f6124f4
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (8/10)