Trifluoroacetic acid methylene chloride → 4-Ethoxycarbonylmethoxy-3-methyl-benzofuran-2-carboxylic acid

HRID 29481Notes

Reaction equation

HRID 29481 reaction equation
C([O:5][C:6]([C:8]1[O:9][C:10]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:11]=2[C:12]=1[CH3:13])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[CH2:23]([O:22][C:20]([CH2:19][O:18][C:14]1[C:11]2[C:12]([CH3:13])=[C:8]([C:6]([OH:7])=[O:5])[O:9][C:10]=2[CH:17]=[CH:16][CH:15]=1)=[O:21])[CH3:24]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 687149594-Ethoxycarbonylmethoxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester

Product 1

HCID 687113724-Ethoxycarbonylmethoxy-3-methyl-benzofuran-2-carboxylic acid

Procedure

The above 4-ethoxycarbonylmethoxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester was dissolved into a 40% TFA/methylene chloride solution, and stirred at room temperature for 4 hours. Evaporation of solvent gave 4-ethoxycarbonylmethoxy-3-methyl-benzofuran-2-carboxylic acid in quantitative yield.

Workup

  1. customEvaporation of solvent

Sources & evidence

ORD record
ord-f784bd529321459a945380ab3b571aa5
Source dataset
uspto-grants-2008_09
Patent number
US07420001B2

Reaction notes

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