4-Hydroxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester → 4-Hydroxy-3-methyl-1-benzofuran-2-carboxylic acid

HRID 29486Notes

Reaction equation

HRID 29486 reaction equation
C([O:5][C:6]([C:8]1[O:9][C:10]2[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[C:11]=2[C:12]=1[CH3:13])=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[OH:18][C:14]1[C:11]2[C:12]([CH3:13])=[C:8]([C:6]([OH:7])=[O:5])[O:9][C:10]=2[CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 1

HCID 138494564-Hydroxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester

Product 1

HCID 94976624-Hydroxy-3-methyl-1-benzofuran-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

4-Hydroxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester (Example 156, Step 2) was dissolved in a 40% TFA/methylene chloride solution at room temperature for 4 hours. 4-Hydroxy-3-methyl-benzofuran-2-carboxylic acid was isolated as a white powder by evaporation of the solvent.

Sources & evidence

ORD record
ord-b2d27b4ac385476d9e797053ae00c82d
Source dataset
uspto-grants-2008_09
Patent number
US07420001B2

Reaction notes

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