Trifluoroacetic acid methylene chloride → 4-Dimethylcarbamoylmethoxy-3-methyl-benzofuran-2-carboxylic acid

HRID 29490Notes

Reaction equation

HRID 29490 reaction equation
C([O:5][C:6]([C:8]1[O:9][C:10]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH2:19][C:20](=[O:24])[N:21]([CH3:23])[CH3:22])[C:11]=2[C:12]=1[CH3:13])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[CH3:22][N:21]([CH3:23])[C:20]([CH2:19][O:18][C:14]1[C:11]2[C:12]([CH3:13])=[C:8]([C:6]([OH:7])=[O:5])[O:9][C:10]=2[CH:17]=[CH:16][CH:15]=1)=[O:24]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 687161964-Dimethylcarbamoylmethoxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester

Product 1

HCID 687160664-Dimethylcarbamoylmethoxy-3-methyl-benzofuran-2-carboxylic acid

Procedure

The above 4-dimethylcarbamoylmethoxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester was dissolved into a 40% TFA/methylene chloride solution, and stirred at room temperature for four hours. Evaporation of solvent gave 4-dimethylcarbamoylmethoxy-3-methyl-benzofuran-2-carboxylic acid in quantitative yield.

Workup

  1. customEvaporation of solvent

Sources & evidence

ORD record
ord-20054ef6058c40f197ab5bec19c873c0
Source dataset
uspto-grants-2008_09
Patent number
US07420001B2

Reaction notes

Loading…