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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29490Generated: October 28, 2026

Trifluoroacetic acid methylene chloride → 4-Dimethylcarbamoylmethoxy-3-methyl-benzofuran-2-carboxylic acid

https://huagongshe.com/reaction/29490

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acid methylene chlorideHCID 21863450—
Reactant4-Dimethylcarbamoylmethoxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl esterHCID 68716196—
Product4-Dimethylcarbamoylmethoxy-3-methyl-benzofuran-2-carboxylic acidHCID 68716066—

Reaction Steps

The above 4-dimethylcarbamoylmethoxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester was dissolved into a 40% TFA/methylene chloride solution, and stirred at room temperature for four hours. Evaporation of solvent gave 4-dimethylcarbamoylmethoxy-3-methyl-benzofuran-2-carboxylic acid in quantitative yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07420001B2
Source datasetuspto-grants-2008_09
ORD IDord-20054ef6058c40f197ab5bec19c873c0
Source noteuspto-grants-2008_09