反应详情

Biphenyl (46.3 g, 0.3 mol) was dissolved in 500 ml of chloroform. The solution was cooled in an ice/water bath. Chlorosulfonic acid (19.9 ml, 1 eq) was added dropwise over 30 min. The ice/water bath was removed and the reaction mixture was stirred at room temperature overnight. The reaction mixture was filtered and the solid was washed with CHCl3 to provide 41.2 g of biphenyl-4-sulfonic acid as a white solid.

1. temperatureThe solution was cooled in an ice/water bath
2. customThe ice/water bath was removed
3. filtrationThe reaction mixture was filtered
4. washthe solid was washed with CHCl3