反应详情

温度

-5 °C

Biphenyl-4-sulfonic acid (30 g) was mixed with trifluoroacetic acid and a suspension was formed. The mixture was cooled to −5° C. Fuming nitric acid (12.8 ml) was added dropwise over 30 min. The reaction mixture was stirred at 0° C. for 2 h. The chloroform was removed in vacuo and the residue was recrystallized from acetic acid to provide 15 g of 4′-nitro-biphenyl-4-sulfonic acid, obtained as white crystals.

1. customa suspension was formed
2. customThe chloroform was removed in vacuo
3. customthe residue was recrystallized from acetic acid