Potassium Cation → 3-tert-butoxycarbonyl-7-chloro-6-(2,5'-difluoro-2'-methoxy-biphenyl-4-ylmethylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine
Reaction equation
[BH:30]([OH:31])[OH:32].[Br:1][c:2]1[c:3]([F:29])[cH:4][c:5]([CH2:6][S:7][c:8]2[c:9]([Cl:26])[cH:10][cH:11][c:12]3[c:18]2[CH2:17][CH2:16][N:15]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:14][CH2:13]3)[cH:27][cH:28]1.[C:42](=[O:43])([O-:44])[O-:45].[F:33][c:34]1[cH:35][cH:36][c:37]([O:40][CH3:41])[cH:38][cH:39]1.[K+:46].[K+:47].[O:67]1[CH2:68][CH2:69][O:70][CH2:71][CH2:72]1.[OH2:73].[Pd:74]([Cl:75])[Cl:76].[c:48]1([P:49]([c:50]2[cH:51][cH:52][cH:53][cH:54][cH:55]2)[c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[cH:62][cH:63][cH:64][cH:65][cH:66]1.[c:77]1([P:78]([c:79]2[cH:80][cH:81][cH:82][cH:83][cH:84]2)[c:85]2[cH:86][cH:87][cH:88][cH:89][cH:90]2)[cH:91][cH:92][cH:93][cH:94][cH:95]1.[c:96]1([P:97]([c:98]2[cH:99][cH:100][cH:101][cH:102][cH:103]2)[c:104]2[cH:105][cH:106][cH:107][cH:108][cH:109]2)[cH:110][cH:111][cH:112][cH:113][cH:114]1>>[c:2]1(-[c:36]2[cH:35][c:34]([F:33])[cH:39][cH:38][c:37]2[O:40][CH3:41])[c:3]([F:29])[cH:4][c:5]([CH2:6][S:7][c:8]2[c:9]([Cl:26])[cH:10][cH:11][c:12]3[c:18]2[CH2:17][CH2:16][N:15]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:14][CH2:13]3)[cH:27][cH:28]1Participants
10
Reactant 9
Product 1
Sources & evidence
- ORD record
- ord-adb5701fe15b4f9e8affa9bbe7adca07
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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