Dichloromethane → N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-3-furansulfonamide

HRID 295033Notes

Reaction equation

[Cl:49][CH2:50][Cl:51].[F:42][C:43]([F:44])([F:45])[C:46]([OH:47])=[O:48].[NH2:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:26]3[c:27]([F:41])[c:28]([NH:32][S:33](=[O:34])(=[O:35])[c:36]4[cH:37][o:38][cH:39][cH:40]4)[cH:29][cH:30][cH:31]3)[n:10][c:11]([CH:13]3[CH2:14][CH2:15][N:16]([C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:17][CH2:18]3)[s:12]2)[n:7]1>>[NH2:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:26]3[c:27]([F:41])[c:28]([NH:32][S:33](=[O:34])(=[O:35])[c:36]4[cH:37][o:38][cH:39][cH:40]4)[cH:29][cH:30][cH:31]3)[n:10][c:11]([CH:13]3[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 579898381,1-Dimethylethyl 4-(5-(2-amino-4-pyrimidinyl)-4-{2-fluoro-3-[(3-furanylsulfonyl)amino]phenyl}-1,3-thiazol-2-yl)-1-piperidinecarboxylate

Product 1

HCID 57989716N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-3-furansulfonamide

Sources & evidence

ORD record: ord-90ba8e51e8db45e3bb824753b793afb7
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…