Methanol → 3-(4-Carboxybenzyl)-7-chloro-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxylic acid methyl ester

HRID 295274Notes

Reaction equation

HRID 295274 reaction equation
[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6](-[c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[c:7]2[cH:8][c:9]([Cl:27])[cH:10][cH:11][c:12]2[c:13](=[O:26])[c:14]1[CH2:15][c:16]1[cH:17][cH:18][c:19]([C:22](=[O:23])[O:24][CH3:25])[cH:20][cH:21]1.[CH3:36][OH:37].[Li+:35].[OH-:34]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6](-[c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[c:7]2[cH:8][c:9]([Cl:27])[cH:10][cH:11][c:12]2[c:13](=[O:26])[c:14]1[CH2:15][c:16]1[cH:17][cH:18][c:19]([C:22](=[O:23])[OH:24])[cH:20][cH:21]1

Participants

5

Reactant 4

HCID 887MethanolHCID 961HydroxideHCID 28486Lithium ionHCID 598461727-Chloro-3-(4-methoxycarbonyl-benzyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Product 1

HCID 251817183-(4-Carboxybenzyl)-7-chloro-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-36086d1472394476be051c7c6d6b8f19
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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