Dichloromethane → Trifluoro-methanesulfonic acid 7-(piperidin-4-ylmethyl-propyl-amino)-5,6,7,8-tetrahydro-naphthalen-2-yl ester

HRID 295370Notes

Reaction equation

HRID 295370 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][N:15]([CH:16]2[CH2:17][c:18]3[cH:19][c:20]([O:26][S:27](=[O:28])(=[O:29])[C:30]([F:31])([F:32])[F:33])[cH:21][cH:22][c:23]3[CH2:24][CH2:25]2)[CH2:34][CH2:35][CH3:36])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH2:44]([Cl:45])[Cl:46].[OH:37][C:38]([C:39]([F:40])([F:41])[F:42])=[O:43]>>[NH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][N:15]([CH:16]2[CH2:17][c:18]3[cH:19][c:20]([O:26][S:27](=[O:28])(=[O:29])[C:30]([F:31])([F:32])[F:33])[cH:21][cH:22][c:23]3[CH2:24][CH2:25]2)[CH2:34][CH2:35][CH3:36])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 865890904-{[Propyl-(7-trifluoromethanesulfonyloxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-amino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 21362810Trifluoro-methanesulfonic acid 7-(piperidin-4-ylmethyl-propyl-amino)-5,6,7,8-tetrahydro-naphthalen-2-yl ester

Sources & evidence

ORD record
ord-c792c241b7444e5c8ef7957558d47359
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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